Study on the Mechanism of Pollen Typhae in the Treatment of Schizophrenia Based on Network Pharmacology

Abstract

To explore the lipid-lowering mechanism of walnut meal based on network pharmacology. The active components and corresponding potential targets of Pollen Typhae were obtained through TCMSP database and literature mining; Use genecards, OMIM and other databases to predict and screen schizophrenia related genes; Cytoscape 3.7.2 software was used to construct the "drug active ingredient disease target" network to form the component and target interaction relationship of Pollen Typhae in the treatment of schizophrenia, and go function and KEGG pathway enrichment analysis were carried out. Eight active components of walnut meal were screened, six of which had 135 schizophrenia related targets, AKT1, IL6 and IL1-β, CASP3, VEGFA, JUN and PTGS2 may be the key targets of schizophrenia. The main signal pathways are lipid and atherosclerosis, fluid shear stress and atherosclerosis, chemical carcinogenesis - receptor activation, AGE-RAGE signaling pathway in diabetic complexes, human cytomegalovirus infection, TNF signaling pathway Chemical carcinogenesis - reactive oxygen species. Pollen Typhae can treat schizophrenia through multi-component, multi-target and multi-channel. The most targeted components are kaempferol, luteolin and quercetin; The most affected targets were PPARG, PTGS1, PTGS2, NCOA2 and CASP3.