Intrahepatic Cholestasis of Pregnancy Associated Vitamin D deficiency

  • Jin Chen, Xiangdong Ding, Kai Yang, Ping Yin

Abstract

Here, we investigated the serum vitamin D level in pregnant women with ICP. Serum level of 25(OH)D, from 125 pregnant women with ICP and and 95 healthy women with uncomplicated pregnancies were measured. Serum 25(OH)D level in pregnant women with ICP and healthy pregnant women were significantly different (17.25±7.02 ng/ml, 23.36±4.64 ng/ml, respectively). ICP patients had a higher rate of vitamin D deficiency and insufficiency relative to control group (P all<0.001). Serum 25(OH)D level in pregnant women with severe ICP was lower than in those with mild ICP. Importantly, low 25(OH)D serum level are associated with high level of total bile acid (TBA) in pregnant women with ICP (r=-0.276, P < 0.001). These findings suggest the potential role of vitamin D in the pathogenesis of ICP.

How to Cite
Jin Chen, Xiangdong Ding, Kai Yang, Ping Yin. (1). Intrahepatic Cholestasis of Pregnancy Associated Vitamin D deficiency. Forest Chemicals Review, 1511-1515. Retrieved from http://forestchemicalsreview.com/index.php/JFCR/article/view/294
Issue
July-August 2021
Section
Articles