Anti-Aging Effect of Codnopsis Bulleyana Forrest ex Diels on D-Galactose-Induced Aging Mouse Model

Abstract

Codnopsis bulleyana forrest ex Diels is a natural medicinal and edible homologous plant with good antioxidant properties. The purpose of this study was to investigate its anti-aging effect on mice about water extract of Codnopsis bulleyana forrest ex Diels (cbFeD). In the animal experiment part, the mice were divided into four groups: control group, D-gal group, vitamin E group and cbFeD group (500 mg/kg/day). The results showed that after the cbFeD gavage treatment, the mice gradually increased their body weight, their daily activities were enhanced, and the atrophy of the organ index was improved. In the two behavioral experiments, the latency time of the novelty inhibition feeding test was significantly shortened, and the preference index of the mice to sugar water was also significantly increased. cbFeD restores D-galactose-induced inflammatory responses and organ damage in mouse liver and kidney tissues. Compared with the mice in the model group, cbFeD significantly improved the anti-oxidative stress capacity of the serum, liver and kidney of the mice. In addition, cbFeD treatment can protect the liver and kidney. The effect of cbFeD treatment is also reflected in the reduction of liver function indexes ALT, AST, and ALP, and the levels of renal function indexes CR and UREA are also significantly reduced. These results indicate that cbFeD has obvious anti-aging activity in the D-gal-induced aging mouse model. Played the role of protecting liver and kidney function and enhancing cognition in mice. The mechanism is related to the enhancement of anti-inflammatory effects and alleviation of oxidative stress in aging model mice to a certain extent.